6JIB
Human MTHFD2 in complex with DS44960156
Summary for 6JIB
Entry DOI | 10.2210/pdb6jib/pdb |
Descriptor | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, 4-(5-oxo-1,5-dihydro-2H-[1]benzopyrano[3,4-c]pyridine-3(4H)-carbonyl)benzoic acid, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | inhibitor, folate, cofactor, dehydrogenase, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 72478.70 |
Authors | Suzuki, M.,Matsui, Y.,Kawai, J. (deposition date: 2019-02-20, release date: 2019-06-05, Last modification date: 2023-11-22) |
Primary citation | Kawai, J.,Ota, M.,Ohki, H.,Toki, T.,Suzuki, M.,Shimada, T.,Matsui, S.,Inoue, H.,Sugihara, C.,Matsuhashi, N.,Matsui, Y.,Takaishi, S.,Nakayama, K. Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. Acs Med.Chem.Lett., 10:893-898, 2019 Cited by PubMed: 31223444DOI: 10.1021/acsmedchemlett.9b00069 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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