Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue BQF A 401 |
| Chain | Residue |
| A | TYR84 |
| A | HOH526 |
| A | HOH531 |
| A | ASN87 |
| A | LYS88 |
| A | GLN132 |
| A | PRO309 |
| A | GLY310 |
| A | GLY313 |
| A | PRO314 |
| A | VAL317 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | ARG201 |
| A | ARG233 |
| A | HOH501 |
| A | HOH540 |
| A | HOH543 |
| A | HOH548 |
| A | HOH557 |
| B | ASP216 |
| B | HIS219 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue BQF A 403 |
| Chain | Residue |
| A | GLY200 |
| A | SER231 |
| A | HIS232 |
| A | ARG233 |
| A | THR235 |
| A | LYS237 |
| A | LEU240 |
| A | ALA254 |
| A | ILE256 |
| A | LEU259 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | GLU141 |
| A | ASN204 |
| A | GOL405 |
| A | HOH563 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | GLU141 |
| A | ARG142 |
| A | PHE157 |
| A | GOL404 |
| B | LEU167 |
| B | GOL403 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 406 |
| Chain | Residue |
| A | ASP216 |
| A | HIS219 |
| B | ARG201 |
| B | ARG233 |
| B | HOH531 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue BQF B 401 |
| Chain | Residue |
| B | TYR84 |
| B | ASN87 |
| B | LYS88 |
| B | GLN132 |
| B | PRO309 |
| B | GLY310 |
| B | GLY313 |
| B | PRO314 |
| B | VAL317 |
| B | HOH537 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue BQF B 402 |
| Chain | Residue |
| B | ALA199 |
| B | GLY200 |
| B | SER231 |
| B | HIS232 |
| B | ARG233 |
| B | THR235 |
| B | LYS237 |
| B | LEU240 |
| B | ALA254 |
| B | LEU259 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| A | GOL405 |
| B | LEU167 |
| B | ASP168 |
| B | GLN169 |
| B | HIS219 |
| B | GLU220 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | GLU141 |
| B | PHE157 |
| B | GOL405 |
| B | HOH514 |
| B | HOH520 |
| B | HOH547 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| B | GLU141 |
| B | ARG142 |
| B | PHE157 |
| B | GOL404 |
Functional Information from PROSITE/UniProt
| site_id | PS00766 |
| Number of Residues | 26 |
| Details | THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EeELLnlInkLNnDdnvdgLLVQLPL |
| Chain | Residue | Details |
| A | GLU110-LEU135 | |
| site_id | PS00767 |
| Number of Residues | 9 |
| Details | THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV |
| Chain | Residue | Details |
| A | PRO309-VAL317 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27899380","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16100107","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27899380","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
