6JDX
Crystal structure of AcrIIC2 dimer in complex with partial Nme1Cas9 preprocessed with protease alpha-Chymotrypsin
Summary for 6JDX
Entry DOI | 10.2210/pdb6jdx/pdb |
Descriptor | AcrIIC2, CRISPR-associated endonuclease Cas9, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | crispr-cas9, nme1cas9, nmecas9, anti-crispr, acriic2, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Neisseria meningitidis 8013 More |
Total number of polymer chains | 3 |
Total formula weight | 37246.93 |
Authors | |
Primary citation | Thavalingam, A.,Cheng, Z.,Garcia, B.,Huang, X.,Shah, M.,Sun, W.,Wang, M.,Harrington, L.,Hwang, S.,Hidalgo-Reyes, Y.,Sontheimer, E.J.,Doudna, J.,Davidson, A.R.,Moraes, T.F.,Wang, Y.,Maxwell, K.L. Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nat Commun, 10:2806-2806, 2019 Cited by PubMed: 31243272DOI: 10.1038/s41467-019-10577-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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