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6JDV

Crystal structure of Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in catalytic state

Summary for 6JDV
Entry DOI10.2210/pdb6jdv/pdb
DescriptorCRISPR-associated endonuclease Cas9, sgRNA, target DNA strand, ... (7 entities in total)
Functional Keywordscrispr-cas9, nmecas9, nme1cas9, hydrolase, ternary complex, hydrolase-rna-dna complex, hydrolase/rna/dna
Biological sourceNeisseria meningitidis serogroup C (strain 8013)
More
Total number of polymer chains4
Total formula weight185820.16
Authors
Sun, W.,Yang, J.,Cheng, Z.,Liu, C.,Wang, K.,Huang, X.,Wang, Y. (deposition date: 2019-02-02, release date: 2019-11-06, Last modification date: 2023-11-22)
Primary citationSun, W.,Yang, J.,Cheng, Z.,Amrani, N.,Liu, C.,Wang, K.,Ibraheim, R.,Edraki, A.,Huang, X.,Wang, M.,Wang, J.,Liu, L.,Sheng, G.,Yang, Y.,Lou, J.,Sontheimer, E.J.,Wang, Y.
Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.
Mol.Cell, 76:938-, 2019
Cited by
PubMed: 31668930
DOI: 10.1016/j.molcel.2019.09.025
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

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