6IJI
Crystal structure of PDE10 in complex with inhibitor 2b
Summary for 6IJI
Entry DOI | 10.2210/pdb6iji/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 75730.44 |
Authors | |
Primary citation | Huang, Y.Y.,Yu, Y.F.,Zhang, C.,Chen, Y.,Zhou, Q.,Li, Z.,Zhou, S.,Li, Z.,Guo, L.,Wu, D.,Wu, Y.,Luo, H.B. Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors. J. Med. Chem., 62:3707-3721, 2019 Cited by PubMed: 30888810DOI: 10.1021/acs.jmedchem.9b00224 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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