6IJI
Crystal structure of PDE10 in complex with inhibitor 2b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 324 | 37559.3 | 2 | UniProt (Q9Y233) | Homo sapiens (Human) | |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | G (B) | 2-{2-[5-methyl-1-(pyridin-4-yl)-1H-benzimidazol-2-yl]ethyl}-1H-benzo[de]isoquinoline-1,3(2H)-dione | non-polymer | 432.5 | 1 | Chemie (AEL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 770 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| His 447 | - | expression tag |
| Met 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75118.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 611.9 | |
| All* | Total formula weight | 75730.4 |
