6IG8

Crystal structure of CSF-1R kinase domain with a small molecular inhibitor, JTE-952

Summary for 6IG8

Entry DOI	10.2210/pdb6ig8/pdb
Descriptor	Macrophage colony-stimulating factor 1 receptor, MAGNESIUM ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	csf-1-r, fms proto-oncogene, c-fms, cd115 antigen, kinase, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	36939.87
Authors	Doi, S.,Adachi, T. (deposition date: 2018-09-25, release date: 2019-08-07, Last modification date: 2023-11-22)
Primary citation	Ikegashira, K.,Ikenogami, T.,Yamasaki, T.,Hase, Y.,Yamaguchi, T.,Inagaki, K.,Doi, S.,Adachi, T.,Koga, Y.,Hashimoto, H. Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models. Bioorg.Med.Chem.Lett., 29:115-118, 2019 Cited by PubMed: 30442420 DOI: 10.1016/j.bmcl.2018.10.051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation