6IG8
Crystal structure of CSF-1R kinase domain with a small molecular inhibitor, JTE-952
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage colony-stimulating factor 1 receptor | polymer | 324 | 36280.6 | 1 | UniProt (P07333) Pfam (PF07714) | Homo sapiens (Human) | CSF-1 receptor,M-CSF-R,Proto-oncogene c-Fms |
| 2 | B, C (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | E (A) | (3-{4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl}azetidin-1-yl)(4-{[(2S)-2,3-dihydroxypropoxy]methyl}pyridin-2-yl)methanone | non-polymer | 518.6 | 1 | Chemie (A7O) | |||
| 5 | F (A) | water | water | 18.0 | 370 | Chemie (HOH) |
Sequence modifications
A: 550 - 695 (UniProt: P07333)
A: 742 - 919 (UniProt: P07333)
| PDB | External Database | Details |
|---|---|---|
| Ala 688 | Ser 688 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36280.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 659.3 | |
| All* | Total formula weight | 36939.9 |
