6I8Z
Crystal structure of PTK2 in complex with BI-4464.
Summary for 6I8Z
Entry DOI | 10.2210/pdb6i8z/pdb |
Descriptor | Focal adhesion kinase 1, 3-methoxy-~{N}-(1-methylpiperidin-1-ium-4-yl)-4-[[4-[(3-oxidanylidene-1,2-dihydroinden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide (3 entities in total) |
Functional Keywords | inhibitor, protein kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32803.73 |
Authors | Bader, G.,Zoephel, A. (deposition date: 2018-11-21, release date: 2019-02-20, Last modification date: 2024-01-24) |
Primary citation | Popow, J.,Arnhof, H.,Bader, G.,Berger, H.,Ciulli, A.,Covini, D.,Dank, C.,Gmaschitz, T.,Greb, P.,Karolyi-Ozguer, J.,Koegl, M.,McConnell, D.B.,Pearson, M.,Rieger, M.,Rinnenthal, J.,Roessler, V.,Schrenk, A.,Spina, M.,Steurer, S.,Trainor, N.,Traxler, E.,Wieshofer, C.,Zoephel, A.,Ettmayer, P. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J.Med.Chem., 62:2508-2520, 2019 Cited by PubMed: 30739444DOI: 10.1021/acs.jmedchem.8b01826 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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