6I7N

Trypanothione Reductase from Leismania infantum in complex with TRL156

Summary for 6I7N

Entry DOI	10.2210/pdb6i7n/pdb
Descriptor	Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... (6 entities in total)
Functional Keywords	inhibitor, complex, dimer, oxidoreductase, flavoprotein
Biological source	Leishmania infantum
Total number of polymer chains	2
Total formula weight	108887.70
Authors	Carriles, A.A.,Hermoso, J.A. (deposition date: 2018-11-16, release date: 2019-05-15, Last modification date: 2024-01-24)
Primary citation	Revuelto, A.,Ruiz-Santaquiteria, M.,de Lucio, H.,Gamo, A.,Carriles, A.A.,Gutierrez, K.J.,Sanchez-Murcia, P.A.,Hermoso, J.A.,Gago, F.,Camarasa, M.J.,Jimenez-Ruiz, A.,Velazquez, S. Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase. Acs Infect Dis., 5:873-891, 2019 Cited by PubMed: 30983322 DOI: 10.1021/acsinfecdis.8b00355 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation