6I7N
Trypanothione Reductase from Leismania infantum in complex with TRL156
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006749 | biological_process | glutathione metabolic process |
A | 0015036 | molecular_function | disulfide oxidoreductase activity |
A | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
A | 0034599 | biological_process | cellular response to oxidative stress |
A | 0045454 | biological_process | cell redox homeostasis |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0098869 | biological_process | cellular oxidant detoxification |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006749 | biological_process | glutathione metabolic process |
B | 0015036 | molecular_function | disulfide oxidoreductase activity |
B | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
B | 0034599 | biological_process | cellular response to oxidative stress |
B | 0045454 | biological_process | cell redox homeostasis |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 30 |
Details | binding site for residue FAD A 501 |
Chain | Residue |
A | GLY11 |
A | THR51 |
A | CYS52 |
A | CYS57 |
A | LYS60 |
A | GLY125 |
A | GLY127 |
A | ALA159 |
A | THR160 |
A | GLY161 |
A | SER178 |
A | GLY13 |
A | ARG287 |
A | LEU294 |
A | ASP327 |
A | MET333 |
A | LEU334 |
A | THR335 |
A | PRO336 |
A | ALA338 |
A | HOH604 |
A | HOH605 |
A | SER14 |
B | HIS461 |
A | GLY15 |
A | VAL34 |
A | ASP35 |
A | ALA46 |
A | ALA47 |
A | GLY50 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue GOL A 502 |
Chain | Residue |
A | SER2 |
A | ARG3 |
A | ALA4 |
A | ASP6 |
A | GLU154 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 503 |
Chain | Residue |
A | TYR221 |
A | ASP224 |
A | LEU225 |
A | ARG228 |
A | ARG235 |
A | HOH616 |
site_id | AC4 |
Number of Residues | 29 |
Details | binding site for residue FAD B 501 |
Chain | Residue |
A | HIS461 |
B | GLY11 |
B | ALA12 |
B | SER14 |
B | GLY15 |
B | VAL34 |
B | ASP35 |
B | ALA46 |
B | ALA47 |
B | GLY50 |
B | THR51 |
B | CYS52 |
B | CYS57 |
B | LYS60 |
B | GLY127 |
B | ALA159 |
B | THR160 |
B | GLY161 |
B | TYR198 |
B | ARG287 |
B | LEU294 |
B | GLY326 |
B | ASP327 |
B | MET333 |
B | LEU334 |
B | THR335 |
B | PRO336 |
B | HOH607 |
B | HOH608 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue H6H B 502 |
Chain | Residue |
B | LEU17 |
B | GLU18 |
B | SER109 |
B | TYR110 |
B | MET113 |
B | HOH638 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue GOL B 503 |
Chain | Residue |
B | SER420 |
B | ASN421 |
B | HOH613 |
B | HOH628 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue SO4 B 504 |
Chain | Residue |
B | ARG228 |
B | GLY229 |
B | ARG235 |
B | HOH605 |
B | HOH619 |
Functional Information from PROSITE/UniProt
site_id | PS00076 |
Number of Residues | 11 |
Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
Chain | Residue | Details |
A | GLY49-PRO59 |