6I55
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with N-(2,2-Diphenylethyl)-4-hydroxy-1,2,5-thiadiazole-3-carboxamide
Summary for 6I55
Entry DOI | 10.2210/pdb6i55/pdb |
Descriptor | Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total) |
Functional Keywords | dhodh, plasmodium falciparum, oxidoreductase, inhibitor complex |
Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
Total number of polymer chains | 2 |
Total formula weight | 93580.57 |
Authors | Goyal, P.,Sainas, S.,Pippione, A.C.,Boschi, D.,Al-Kadaraghi, S. (deposition date: 2018-11-12, release date: 2018-12-19, Last modification date: 2024-05-15) |
Primary citation | Pippione, A.C.,Sainas, S.,Goyal, P.,Fritzson, I.,Cassiano, G.C.,Giraudo, A.,Giorgis, M.,Tavella, T.A.,Bagnati, R.,Rolando, B.,Caing-Carlsson, R.,Costa, F.T.M.,Andrade, C.H.,Al-Karadaghi, S.,Boschi, D.,Friemann, R.,Lolli, M.L. Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies. Eur J Med Chem, 163:266-280, 2018 Cited by PubMed: 30529545DOI: 10.1016/j.ejmech.2018.11.044 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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