6I55

Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with N-(2,2-Diphenylethyl)-4-hydroxy-1,2,5-thiadiazole-3-carboxamide

Summary for 6I55

• Entry DOI: 10.2210/pdb6i55/pdb
• Descriptor: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total)
• Functional Keywords: dhodh, plasmodium falciparum, oxidoreductase, inhibitor complex
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Total number of polymer chains: 2
• Total formula weight: 93580.57

Authors

Goyal, P.,Sainas, S.,Pippione, A.C.,Boschi, D.,Al-Kadaraghi, S. (deposition date: 2018-11-12, release date: 2018-12-19)

• Primary citation: Pippione, A.C.,Sainas, S.,Goyal, P.,Fritzson, I.,Cassiano, G.C.,Giraudo, A.,Giorgis, M.,Tavella, T.A.,Bagnati, R.,Rolando, B.,Caing-Carlsson, R.,Costa, F.T.M.,Andrade, C.H.,Al-Karadaghi, S.,Boschi, D.,Friemann, R.,Lolli, M.L.; Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.; Eur J Med Chem, 163:266-280, 2018; PubMed: 30529545; DOI: 10.1016/j.ejmech.2018.11.044

Experimental method

X-RAY DIFFRACTION (1.98 Å)