6I55
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) co-crystallized with N-(2,2-Diphenylethyl)-4-hydroxy-1,2,5-thiadiazole-3-carboxamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dihydroorotate dehydrogenase | polymer | 405 | 45852.5 | 2 | UniProt (Q54A96) Pfam (PF01180) In PDB | Plasmodium falciparum (malaria parasite P. falciparum) | |
2 | A, B | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) | |||
3 | A, B | OROTIC ACID | non-polymer | 156.1 | 2 | Chemie (ORO) | |||
4 | A, B | N-(2,2-Diphenylethyl)-4-hydroxy-1,2,5-thiadiazole-3-carboxamide | non-polymer | 325.4 | 2 | Chemie (DZB) | |||
5 | water | water | 18.0 | 344 | Chemie (HOH) |
Sequence modifications
A, B: 158 - 569 (UniProt: Q54A96)
PDB | External Database | Details |
---|---|---|
Met 135 | - | initiating methionine |
His 136 | - | expression tag |
His 137 | - | expression tag |
His 138 | - | expression tag |
His 139 | - | expression tag |
His 140 | - | expression tag |
His 141 | - | expression tag |
Ser 142 | - | expression tag |
Ser 143 | - | expression tag |
Gly 144 | - | expression tag |
Val 145 | - | expression tag |
Asp 146 | - | expression tag |
Leu 147 | - | expression tag |
Gly 148 | - | expression tag |
Thr 149 | - | expression tag |
Glu 150 | - | expression tag |
Asn 151 | - | expression tag |
Leu 152 | - | expression tag |
Tyr 153 | - | expression tag |
Phe 154 | - | expression tag |
Gln 155 | - | expression tag |
Ser 156 | - | expression tag |
Met 157 | - | expression tag |
- | Ser 384 | deletion |
- | Thr 385 | deletion |
- | Tyr 386 | deletion |
- | Asn 387 | deletion |
- | Glu 388 | deletion |
- | Asp 389 | deletion |
- | Asn 390 | deletion |
- | Lys 391 | deletion |
- | Ile 392 | deletion |
- | Val 393 | deletion |
- | Glu 394 | deletion |
- | Lys 395 | deletion |
- | Lys 396 | deletion |
- | Asn 397 | deletion |
- | Asn 398 | deletion |
- | Phe 399 | deletion |
- | Asn 400 | deletion |
- | Lys 401 | deletion |
- | Asn 402 | deletion |
- | Asn 403 | deletion |
- | Ser 404 | deletion |
- | His 405 | deletion |
- | Met 406 | deletion |
- | Met 407 | deletion |
- | Lys 408 | deletion |
- | Asp 409 | deletion |
- | Ala 410 | deletion |
- | Lys 411 | deletion |
- | Asp 412 | deletion |
- | Asn 413 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 91704.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1875.7 | |
All* | Total formula weight | 93580.6 |