6I45

Crystal structure of I13V/I62V/V77I South African HIV-1 subtype C protease containing a D25A mutation

Summary for 6I45

Entry DOI	10.2210/pdb6i45/pdb
Descriptor	Protease, SODIUM ION, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
Functional Keywords	hiv, aids, human, protease, hydrolase, apo
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	1
Total formula weight	10837.87
Authors	Sherry, D.,Pandian, R.,Achilonu, I.A.,Dirr, H.W.,Sayed, Y. (deposition date: 2018-11-09, release date: 2020-02-26, Last modification date: 2024-01-24)
Primary citation	Sherry, D.,Pandian, R.,Sayed, Y. Non-active site mutations in the HIV protease: Diminished drug binding affinity is achieved through modulating the hydrophobic sliding mechanism. Int.J.Biol.Macromol., 217:27-41, 2022 Cited by PubMed: 35817239 DOI: 10.1016/j.ijbiomac.2022.07.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation