6I0W

Human Carbonic Anhydrase II in complex with 4-Methoxybenzenesulfonamide

Summary for 6I0W

Entry DOI	10.2210/pdb6i0w/pdb
Related	6GDC 6GM9 6HQX 6HR3 6HXD
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (8 entities in total)
Functional Keywords	lyase, inhibitor, complex, co2 conversion
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	31509.78
Authors	Gloeckner, S.,Heine, A.,Klebe, G. (deposition date: 2018-10-26, release date: 2019-11-20, Last modification date: 2024-01-24)
Primary citation	Glockner, S.,Ngo, K.,Sager, C.P.,Hufner-Wulsdorf, T.,Heine, A.,Klebe, G. Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors. Acs Chem.Biol., 15:675-685, 2020 Cited by PubMed: 32027480 DOI: 10.1021/acschembio.9b00895 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.04 Å)

Structure validation