6I02

Structure of human D-glucuronyl C5 epimerase in complex with product

Summary for 6I02

• Entry DOI: 10.2210/pdb6i02/pdb
• Related: 6HZZ 6I01
• Descriptor: D-glucuronyl C5-epimerase, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (14 entities in total)
• Functional Keywords: c5-epimerase, heparan sulfate, isomerase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 129298.73

Authors

Debarnot, C.,Monneau, Y.R.,Roig-Zamboni, V.,Le Narvor, C.,Goulet, A.,Fadel, F.,Vives, R.R.,Bonnaffe, D.,Lortat-Jacob, H.,Bourne, Y. (deposition date: 2018-10-24, release date: 2019-04-03, Last modification date: 2024-01-24)

• Primary citation: Debarnot, C.,Monneau, Y.R.,Roig-Zamboni, V.,Delauzun, V.,Le Narvor, C.,Richard, E.,Henault, J.,Goulet, A.,Fadel, F.,Vives, R.R.,Priem, B.,Bonnaffe, D.,Lortat-Jacob, H.,Bourne, Y.; Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.; Proc.Natl.Acad.Sci.USA, 116:6760-6765, 2019; PubMed: 30872481; DOI: 10.1073/pnas.1818333116

Experimental method

X-RAY DIFFRACTION (2.45 Å)