6I02
Structure of human D-glucuronyl C5 epimerase in complex with product
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| A | 0047464 | molecular_function | heparosan-N-sulfate-glucuronate 5-epimerase activity |
| B | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| B | 0047464 | molecular_function | heparosan-N-sulfate-glucuronate 5-epimerase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30872481","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I01","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30872481","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30872481","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"F1QR43","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Site: {"description":"Critical for catalysis","evidences":[{"source":"UniProtKB","id":"F1QR43","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Critical for catalysis","evidences":[{"source":"PubMed","id":"30872481","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30872481","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30872481","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I02","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
