6HYU

Crystal structure of DHX8 helicase bound to single stranded poly-adenine RNA

6HYU の概要

• エントリーDOI: 10.2210/pdb6hyu/pdb
• 分子名称: ATP-dependent RNA helicase DHX8, RNA (5'-R(*AP*AP*AP*AP*AP*A)-3'), RNA (5'-R(*A*AP*A)-3'), ... (5 entities in total)
• 機能のキーワード: helicase, splicing, rna, rna binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 156580.13

構造登録者

Felisberto-Rodrigues, C.,Thomas, J.C.,McAndrew, P.C.,Le Bihan, Y.V.,Burke, R.,Workman, P.,van Montfort, R.L.M. (登録日: 2018-10-22, 公開日: 2019-08-28, 最終更新日: 2024-05-15)

• 主引用文献: Felisberto-Rodrigues, C.,Thomas, J.C.,McAndrew, C.,Le Bihan, Y.V.,Burke, R.,Workman, P.,van Montfort, R.L.M.; Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.; Biochem.J., 476:2521-2543, 2019; PubMed: 31409651; DOI: 10.1042/BCJ20190383

実験手法

X-RAY DIFFRACTION (3.22 Å)