6HXW
structure of human CD73 in complex with antibody IPH53
Summary for 6HXW
Entry DOI | 10.2210/pdb6hxw/pdb |
Descriptor | 5'-nucleotidase, IPH53 heavy chain, IPH53 light chain, ... (6 entities in total) |
Functional Keywords | inhibitor antibody, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 214366.93 |
Authors | Roussel, A.,Amigues, B. (deposition date: 2018-10-18, release date: 2019-08-28, Last modification date: 2020-07-29) |
Primary citation | Perrot, I.,Michaud, H.A.,Giraudon-Paoli, M.,Augier, S.,Docquier, A.,Gros, L.,Courtois, R.,Dejou, C.,Jecko, D.,Becquart, O.,Rispaud-Blanc, H.,Gauthier, L.,Rossi, B.,Chanteux, S.,Gourdin, N.,Amigues, B.,Roussel, A.,Bensussan, A.,Eliaou, J.F.,Bastid, J.,Romagne, F.,Morel, Y.,Narni-Mancinelli, E.,Vivier, E.,Paturel, C.,Bonnefoy, N. Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies. Cell Rep, 27:2411-2425.e9, 2019 Cited by PubMed: 31116985DOI: 10.1016/j.celrep.2019.04.091 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.78 Å) |
Structure validation
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