6HWO

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1335

Summary for 6HWO

Entry DOI	10.2210/pdb6hwo/pdb
Related	6GXQ
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... (9 entities in total)
Functional Keywords	phosphodiesterase, hydrolase, camp hydrolysis, alternative splicing
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	174297.70
Authors	Singh, A.K.,Brown, D.G. (deposition date: 2018-10-12, release date: 2019-07-24, Last modification date: 2024-01-24)
Primary citation	de Heuvel, E.,Singh, A.K.,Boronat, P.,Kooistra, A.J.,van der Meer, T.,Sadek, P.,Blaazer, A.R.,Shaner, N.C.,Bindels, D.S.,Caljon, G.,Maes, L.,Sterk, G.J.,Siderius, M.,Oberholzer, M.,de Esch, I.J.P.,Brown, D.G.,Leurs, R. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg.Med.Chem., 27:4013-4029, 2019 Cited by PubMed: 31378593 DOI: 10.1016/j.bmc.2019.06.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation