6HUG

CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38.

6HUG の概要

• エントリーDOI: 10.2210/pdb6hug/pdb
• EMDBエントリー: 0275
• 分子名称: Gamma-aminobutyric acid receptor subunit alpha-1, (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, Gamma-aminobutyric acid receptor subunit beta-3, ... (10 entities in total)
• 機能のキーワード: gabaar, ptx, membrane, channel, nanobody, megabody, cys-loop, plgic, inhibition, signalling, cns, neurons, chloride, ion, gaba, picrotoxin, membrane protein
• 由来する生物種: Bos taurus (Bovine); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 330974.45

構造登録者

Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Jasenko, Z.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. (登録日: 2018-10-08, 公開日: 2019-01-02, 最終更新日: 2022-03-30)

• 主引用文献: Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Zivanov, J.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R.; GABAAreceptor signalling mechanisms revealed by structural pharmacology.; Nature, 565:454-459, 2019; PubMed: 30602790; DOI: 10.1038/s41586-018-0832-5

実験手法

ELECTRON MICROSCOPY (3.1 Å)