6HP0

Complex of Neuraminidase from H1N1 Influenza Virus in Complex with Oseltamivir Triazol Derivative

Summary for 6HP0

• Entry DOI: 10.2210/pdb6hp0/pdb
• Descriptor: Neuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: neuraminidase, influenza, complex, inhibitor, viral protein
• Biological source: Influenza A virus (A/Texas/17/2009(H1N1))
• Total number of polymer chains: 4
• Total formula weight: 179477.47

Authors

Pachl, P.,Pokorna, J. (deposition date: 2018-09-19, release date: 2019-09-11, Last modification date: 2024-01-24)

• Primary citation: Zima, V.,Albinana, C.B.,Rojikova, K.,Pokorna, J.,Pachl, P.,Rezacova, P.,Hudlicky, J.,Navratil, V.,Majer, P.,Konvalinka, J.,Kozisek, M.,Machara, A.; Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.; Bioorg.Med.Chem., 27:2935-2947, 2019; PubMed: 31128993; DOI: 10.1016/j.bmc.2019.05.024

Experimental method

X-RAY DIFFRACTION (1.88 Å)