6HN8

Structure of BM3 heme domain in complex with troglitazone

Summary for 6HN8

• Entry DOI: 10.2210/pdb6hn8/pdb
• Descriptor: Bifunctional cytochrome P450/NADPH--P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE, ... (4 entities in total)
• Functional Keywords: cytochrome p450, monooxygenase, heme binding, antidiabetic, troglitazone, oxidoreductase
• Biological source: Bacillus megaterium
• Total number of polymer chains: 2
• Total formula weight: 106937.65

Authors

Jeffreys, L.,Munro, A.W.M.,Leys, D. (deposition date: 2018-09-14, release date: 2019-10-09, Last modification date: 2024-01-24)

• Primary citation: Jeffreys, L.,Leys, D.,Munro, A.W.M.; Oxidation of antidiabetic compounds by cytochrome P450 BM3; To be published,

Experimental method

X-RAY DIFFRACTION (1.997 Å)