6HM7

CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE (SYK) IN COMPLEX WITH A 2-(PHENOXYMETHYL)PYRIDINE INHIBITOR

Summary for 6HM7

• Entry DOI: 10.2210/pdb6hm7/pdb
• Related: 6HM6
• Descriptor: Tyrosine-protein kinase SYK, 7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{H}-3-benzazepine, BROMIDE ION, ... (6 entities in total)
• Functional Keywords: sk363, syk, non-receptor tyrosine kinase, spleen tyrosine kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 32889.35

Authors

Somers, D.O. (deposition date: 2018-09-12, release date: 2018-10-10, Last modification date: 2018-10-17)

• Primary citation: Barker, M.D.,Liddle, J.,Atkinson, F.L.,Wilson, D.M.,Dickson, M.C.,Ramirez-Molina, C.,Lewis, H.,Davis, R.P.,Somers, D.O.,Neu, M.,Jones, E.,Watson, R.; Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease.; Bioorg. Med. Chem. Lett., 28:3458-3462, 2018; PubMed: 30249354; DOI: 10.1016/j.bmcl.2018.09.022

Experimental method

X-RAY DIFFRACTION (1.64 Å)