6HM7
CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE (SYK) IN COMPLEX WITH A 2-(PHENOXYMETHYL)PYRIDINE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase SYK | polymer | 276 | 32104.9 | 1 | UniProt (P43405) Pfam (PF07714) | Homo sapiens (Human) | Spleen tyrosine kinase,p72-Syk |
| 2 | B (A) | 7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{H}-3-benzazepine | non-polymer | 374.5 | 1 | Chemie (GDH) | |||
| 3 | C, D, E (A) | BROMIDE ION | non-polymer | 79.9 | 3 | Chemie (BR) | |||
| 4 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | G (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | H (A) | water | water | 18.0 | 326 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32104.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 784.4 | |
| All* | Total formula weight | 32889.4 |
