6HL7

Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with mutated active site (R109A/K138A) and N-carbamoyl-L-phosphate bound

Summary for 6HL7

• Entry DOI: 10.2210/pdb6hl7/pdb
• Descriptor: Aspartate transcarbamoylase, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER (3 entities in total)
• Functional Keywords: falciparum malaria pyrimidine biosynthesis trimer mutant transferase carbamoyl-phospahte, transferase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Total number of polymer chains: 3
• Total formula weight: 120640.43

Authors

Bosch, S.S.,Lunev, S.,Wrenger, C.,Groves, M.R. (deposition date: 2018-09-10, release date: 2018-09-26, Last modification date: 2024-01-24)

• Primary citation: Bosch, S.S.,Lunev, S.,Batista, F.A.,Linzke, M.,Kronenberger, T.,Domling, A.S.S.,Groves, M.R.,Wrenger, C.; Molecular Target Validation of Aspartate Transcarbamoylase fromPlasmodium falciparumby Torin 2.; Acs Infect Dis., 6:986-999, 2020; PubMed: 32129597; DOI: 10.1021/acsinfecdis.9b00411

Experimental method

X-RAY DIFFRACTION (2.5 Å)