6HL7
Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with mutated active site (R109A/K138A) and N-carbamoyl-L-phosphate bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Aspartate transcarbamoylase | polymer | 348 | 40119.5 | 3 | UniProt (O15804) Pfam (PF02729) Pfam (PF00185) | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 2 | D, E (A, C) | PHOSPHORIC ACID MONO(FORMAMIDE)ESTER | non-polymer | 141.0 | 2 | Chemie (CP) | |||
| 3 | F, G, H (A, B, C) | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A, B, C: 37 - 375 (UniProt: O15804)
| PDB | External Database | Details |
|---|---|---|
| Ala 109 | Arg 109 | engineered mutation |
| Ala 138 | Lys 138 | engineered mutation |
| Ala 376 | - | expression tag |
| Trp 377 | - | expression tag |
| Ser 378 | - | expression tag |
| His 379 | - | expression tag |
| Pro 380 | - | expression tag |
| Gln 381 | - | expression tag |
| Phe 382 | - | expression tag |
| Glu 383 | - | expression tag |
| Lys 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 120358.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 282.0 | |
| All* | Total formula weight | 120640.4 |
