6HL7

Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with mutated active site (R109A/K138A) and N-carbamoyl-L-phosphate bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Aspartate transcarbamoylase	polymer	348	40119.5	3	UniProt (O15804) Pfam (PF02729) Pfam (PF00185) In PDB	Plasmodium falciparum (malaria parasite P. falciparum)
2	A, C	PHOSPHORIC ACID MONO(FORMAMIDE)ESTER	non-polymer		141.0	2	Chemie (CP)
3		water	water		18.0	42	Chemie (HOH)

Sequence modifications

A, B, C: 37 - 375 (UniProt: O15804)

PDB	External Database	Details
Ala 109	Arg 109	engineered mutation
Ala 138	Lys 138	engineered mutation
Ala 376	-	expression tag
Trp 377	-	expression tag
Ser 378	-	expression tag
His 379	-	expression tag
Pro 380	-	expression tag
Gln 381	-	expression tag
Phe 382	-	expression tag
Glu 383	-	expression tag
Lys 384	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	120358.4
Non-Polymers*	Number of molecules	2
	Total formula weight	282.0
All*	Total formula weight	120640.4

*Water molecules are not included.