6HI2
PI3 Kinase Delta in complex with 3{6[(1S,6R)3oxabicyclo[4.1.0]heptan6yl]pyridin2yl}phenol
Summary for 6HI2
| Entry DOI | 10.2210/pdb6hi2/pdb |
| Related | 6hi1 |
| Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 3-[6-[(1~{S},6~{R})-3-oxabicyclo[4.1.0]heptan-6-yl]pyridin-2-yl]phenol (3 entities in total) |
| Functional Keywords | kinase, drug discovery, complex, transferase |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 1 |
| Total formula weight | 108090.99 |
| Authors | |
| Primary citation | Convery, M.A.,Summers, D.,Hobbs, H.,Jamieson, C.,Kennedy, A.R.,Pal, S.,Peace, S.,Pogany, P.,Upton, R. A theoretical and experimental investigation into the conformational bias of aryl cyclopropylpyrans, novel bioisosteres for N-aryl morpholines. to be published, |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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