6HHO

Crystal structure of RIP1 kinase in complex with GSK547

Summary for 6HHO

• Entry DOI: 10.2210/pdb6hho/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 1, 6-[4-[(5~{S})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]carbonylpiperidin-1-yl]pyrimidine-4-carbonitrile (2 entities in total)
• Functional Keywords: inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 69990.60

Authors

Thorpe, J.H.,Harris, P.A. (deposition date: 2018-08-28, release date: 2018-12-12, Last modification date: 2024-01-17)

• Primary citation: Wang, W.,Marinis, J.M.,Beal, A.M.,Savadkar, S.,Wu, Y.,Khan, M.,Taunk, P.S.,Wu, N.,Su, W.,Wu, J.,Ahsan, A.,Kurz, E.,Chen, T.,Yaboh, I.,Li, F.,Gutierrez, J.,Diskin, B.,Hundeyin, M.,Reilly, M.,Lich, J.D.,Harris, P.A.,Mahajan, M.K.,Thorpe, J.H.,Nassau, P.,Mosley, J.E.,Leinwand, J.,Kochen Rossi, J.A.,Mishra, A.,Aykut, B.,Glacken, M.,Ochi, A.,Verma, N.,Kim, J.I.,Vasudevaraja, V.,Adeegbe, D.,Almonte, C.,Bagdatlioglu, E.,Cohen, D.J.,Wong, K.K.,Bertin, J.,Miller, G.; RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.; Cancer Cell, 34:757-774.e7, 2018; PubMed: 30423296; DOI: 10.1016/j.ccell.2018.10.006

Experimental method

X-RAY DIFFRACTION (3.49 Å)