6HFA

Crystal structure of hDM2 in complex with a C-terminal triurea capped peptide chimera foldamer.

Summary for 6HFA

Entry DOI	10.2210/pdb6hfa/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, LM266, 1-[(2~{S})-2-azanyl-3-methyl-butyl]urea (3 entities in total)
Functional Keywords	protein foldamer complex, protein protein interaction inhibitor, urea based chimera foldamer, oncoprotein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	25253.41
Authors	Buratto, J.,Mauran, L.,Goudreau, S.,Fribourg, S.,Guichard, G. (deposition date: 2018-08-21, release date: 2020-07-08, Last modification date: 2023-11-15)
Primary citation	Cussol, L.,Mauran-Ambrosino, L.,Buratto, J.,Belorusova, A.Y.,Neuville, M.,Osz, J.,Fribourg, S.,Fremaux, J.,Dolain, C.,Goudreau, S.R.,Rochel, N.,Guichard, G. Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers. Angew.Chem.Int.Ed.Engl., 2020 Cited by PubMed: 32935897 DOI: 10.1002/anie.202008992 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation