6HDN

Crystal structure of human ATAD2 bromodomain in complex with 3-methyl-8-((8-methyl-8-azabicyclooctan-3-yl)amino)-1,7-naphthyridin-2(1H)-one

Summary for 6HDN

Entry DOI	10.2210/pdb6hdn/pdb
Descriptor	ATPase family AAA domain-containing protein 2, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	inhibitor, atad2, bromodomain, epigenetics, atpase family aaa domain-containing protein 2, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16164.22
Authors	Chung, C. (deposition date: 2018-08-18, release date: 2018-09-26, Last modification date: 2018-10-10)
Primary citation	Bamborough, P.,Chung, C.W.,Furze, R.C.,Grandi, P.,Michon, A.M.,Watson, R.J.,Mitchell, D.J.,Barnett, H.,Prinjha, R.K.,Rau, C.,Sheppard, R.J.,Werner, T.,Demont, E.H. Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors. J. Med. Chem., 61:8321-8336, 2018 Cited by PubMed: 30226378 DOI: 10.1021/acs.jmedchem.8b00862 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation