6HAE

Crystal structure of [Fe]-hydrogenase (Hmd) from Methanococcus aeolicus in complex with FeGP cofactor and methenyl-tetrahydromethanopterin (close form B)

Summary for 6HAE

• Entry DOI: 10.2210/pdb6hae/pdb
• Descriptor: 5,10-methenyltetrahydromethanopterin hydrogenase, GLYCEROL, 1-{4-[(6S,6aR,7R)-3-amino-6,7-dimethyl-1-oxo-1,2,5,6,6a,7-hexahydro-8H-imidazo[1,5-f]pteridin-10-ium-8-yl]phenyl}-1-deoxy-5-O-{5-O-[(S)-{[(1S)-1,3-dicarboxypropyl]oxy}(hydroxy)phosphoryl]-alpha-D-ribofuranosyl}-D-ribitol, ... (10 entities in total)
• Functional Keywords: [fe]-hydrogenase, catalytic cycle, conformational rearrangement, fe-guanylylpyridinol cofactor, methanogenesis, hydride-transfer, tetrahydromethanopterin, c1-metabolism, oxidoreductase
• Biological source: Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
• Total number of polymer chains: 2
• Total formula weight: 78260.32

Authors

Huang, G.,Wagner, T.,Wodrich, M.D.,Ataka, K.,Bill, E.,Ermler, U.,Hu, X.,Shima, S. (deposition date: 2018-08-07, release date: 2019-08-28, Last modification date: 2024-01-17)

• Primary citation: Huang, G.,Wagner, T.,Wodrich, M.D.,Ataka, K.,Bill, E.,Ermler, U.,Hu, X.,Shima, S.; The atomic-resolution crystal structure of activated [Fe]-hydrogenase; Nat Catal, 2019; DOI: 10.1038/s41929-019-0289-4

Experimental method

X-RAY DIFFRACTION (1.85 Å)