6HAE
Crystal structure of [Fe]-hydrogenase (Hmd) from Methanococcus aeolicus in complex with FeGP cofactor and methenyl-tetrahydromethanopterin (close form B)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0015948 | biological_process | methanogenesis |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| A | 0047068 | molecular_function | N5,N10-methenyltetrahydromethanopterin hydrogenase activity |
| A | 0055129 | biological_process | L-proline biosynthetic process |
| K | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
| K | 0006730 | biological_process | one-carbon metabolic process |
| K | 0015948 | biological_process | methanogenesis |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| K | 0047068 | molecular_function | N5,N10-methenyltetrahydromethanopterin hydrogenase activity |
| K | 0055129 | biological_process | L-proline biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | ILE19 |
| A | ASN21 |
| A | GLU94 |
| A | HOH573 |
| A | HOH628 |
| A | HOH676 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | binding site for residue E4M A 402 |
| Chain | Residue |
| A | PRO114 |
| A | PRO150 |
| A | LYS151 |
| A | CYS176 |
| A | GLY203 |
| A | CYS250 |
| A | ASP251 |
| A | MET252 |
| A | SER254 |
| A | FE9415 |
| A | HOH505 |
| A | HOH520 |
| A | HOH521 |
| A | HOH527 |
| A | HOH546 |
| A | HOH552 |
| A | HOH557 |
| A | HOH574 |
| A | HOH651 |
| K | PRO278 |
| K | PHE281 |
| K | THR317 |
| K | SER320 |
| K | MET321 |
| A | SER13 |
| A | HIS14 |
| A | CYS17 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | GLU56 |
| A | HOH503 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SCN A 404 |
| Chain | Residue |
| A | GLY152 |
| A | LYS182 |
| A | HOH590 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SCN A 405 |
| Chain | Residue |
| A | ASN196 |
| A | SER220 |
| A | SCN407 |
| A | HOH511 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SCN A 406 |
| Chain | Residue |
| A | GLU225 |
| A | HOH550 |
| A | HOH584 |
| K | ASP55 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SCN A 407 |
| Chain | Residue |
| A | GLU193 |
| A | LEU195 |
| A | ASN196 |
| A | SCN405 |
| A | HOH511 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SCN A 408 |
| Chain | Residue |
| A | THR237 |
| A | ALA238 |
| A | PHE239 |
| A | HOH575 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue SCN A 409 |
| Chain | Residue |
| A | LEU129 |
| A | LYS130 |
| K | GLU125 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SCN A 410 |
| Chain | Residue |
| A | HIS52 |
| A | VAL127 |
| A | GLY128 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue SCN A 411 |
| Chain | Residue |
| A | ASP110 |
| A | SER111 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 412 |
| Chain | Residue |
| A | GLY153 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue K A 413 |
| Chain | Residue |
| A | LEU51 |
| A | VAL54 |
| A | ILE57 |
| A | HOH653 |
| A | HOH698 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue K A 414 |
| Chain | Residue |
| A | GLU125 |
| A | LYS130 |
| A | VAL131 |
| A | HOH774 |
| site_id | AD6 |
| Number of Residues | 31 |
| Details | binding site for residue FE9 A 415 |
| Chain | Residue |
| A | HOH546 |
| A | HOH547 |
| A | HOH574 |
| A | HOH595 |
| A | HOH665 |
| A | LEU6 |
| A | GLY7 |
| A | GLY9 |
| A | CYS10 |
| A | SER13 |
| A | HIS14 |
| A | SER63 |
| A | ASP64 |
| A | PRO65 |
| A | PRO115 |
| A | CYS118 |
| A | ASP135 |
| A | TRP148 |
| A | LEU149 |
| A | PRO150 |
| A | ILE158 |
| A | ALA175 |
| A | CYS176 |
| A | THR177 |
| A | HIS201 |
| A | PRO202 |
| A | GLY203 |
| A | CYS204 |
| A | VAL205 |
| A | PRO206 |
| A | E4M402 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL K 401 |
| Chain | Residue |
| A | LYS161 |
| K | GLY217 |
| K | TYR218 |
| K | ALA243 |
| K | ASN244 |
| site_id | AD8 |
| Number of Residues | 27 |
| Details | binding site for residue E4M K 402 |
| Chain | Residue |
| A | PRO278 |
| A | PHE281 |
| A | THR317 |
| A | SER320 |
| A | MET321 |
| K | SER13 |
| K | CYS17 |
| K | LYS113 |
| K | PRO114 |
| K | PRO150 |
| K | LYS151 |
| K | CYS176 |
| K | GLY203 |
| K | CYS250 |
| K | ASP251 |
| K | MET252 |
| K | SER254 |
| K | FE9415 |
| K | HOH526 |
| K | HOH554 |
| K | HOH566 |
| K | HOH567 |
| K | HOH573 |
| K | HOH584 |
| K | HOH586 |
| K | HOH613 |
| K | HOH656 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue NA K 403 |
| Chain | Residue |
| K | ASP55 |
| K | GLU56 |
| K | HOH681 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue SCN K 404 |
| Chain | Residue |
| K | GLU193 |
| K | LEU195 |
| K | ASN196 |
| K | TYR218 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue SCN K 405 |
| Chain | Residue |
| A | GLU339 |
| A | HIS340 |
| K | SER266 |
| K | PRO325 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue SCN K 406 |
| Chain | Residue |
| K | SER220 |
| K | GLU221 |
| K | GLU222 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue SCN K 407 |
| Chain | Residue |
| K | GLY152 |
| K | GLY153 |
| K | LYS182 |
| K | HOH565 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue SCN K 408 |
| Chain | Residue |
| K | LEU275 |
| K | HOH701 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue SCN K 409 |
| Chain | Residue |
| K | ARG136 |
| K | GLU140 |
| K | ALA165 |
| K | GLU295 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue SCN K 410 |
| Chain | Residue |
| K | THR237 |
| K | ALA238 |
| K | HOH587 |
| site_id | AE8 |
| Number of Residues | 1 |
| Details | binding site for residue CL K 411 |
| Chain | Residue |
| K | GLY153 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue K K 412 |
| Chain | Residue |
| K | LEU51 |
| K | VAL54 |
| K | ILE57 |
| K | HOH664 |
| K | HOH702 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue K K 413 |
| Chain | Residue |
| K | ASP164 |
| K | ARG192 |
| K | ASN299 |
| K | HOH512 |
| K | HOH659 |
| site_id | AF2 |
| Number of Residues | 8 |
| Details | binding site for residue 2PE K 414 |
| Chain | Residue |
| K | ARG24 |
| K | GLU27 |
| K | MET208 |
| K | LYS209 |
| K | GLY210 |
| K | HOH544 |
| K | HOH549 |
| K | HOH563 |
| site_id | AF3 |
| Number of Residues | 32 |
| Details | binding site for residue FE9 K 415 |
| Chain | Residue |
| K | LEU6 |
| K | GLY7 |
| K | GLY9 |
| K | CYS10 |
| K | SER13 |
| K | HIS14 |
| K | SER63 |
| K | ASP64 |
| K | PRO65 |
| K | PRO114 |
| K | PRO115 |
| K | CYS118 |
| K | ASP135 |
| K | TRP148 |
| K | LEU149 |
| K | PRO150 |
| K | ILE158 |
| K | ALA175 |
| K | CYS176 |
| K | THR177 |
| K | HIS201 |
| K | PRO202 |
| K | GLY203 |
| K | CYS204 |
| K | VAL205 |
| K | PRO206 |
| K | E4M402 |
| K | HOH511 |
| K | HOH526 |
| K | HOH554 |
| K | HOH615 |
| K | HOH635 |
