6H8P

JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Histone H1.4(18-32)K26me3 peptide (15-mer)

6H8P の概要

• エントリーDOI: 10.2210/pdb6h8p/pdb
• 分子名称: Lysine-specific demethylase 4A, Histone H1.4, NICKEL (II) ION, ... (8 entities in total)
• 機能のキーワード: jmjd2a, kdm4a, oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, oxygenase, double-stranded beta helix, dsbh, facial triad, demethylase, histone, jmjc domain, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 92812.16

構造登録者

Chowdhury, R.,Walport, L.J.,Schofield, C.J. (登録日: 2018-08-03, 公開日: 2018-08-15, 最終更新日: 2024-01-17)

• 主引用文献: Walport, L.J.,Hopkinson, R.J.,Chowdhury, R.,Zhang, Y.,Bonnici, J.,Schiller, R.,Kawamura, A.,Schofield, C.J.; Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.; FEBS Lett., 592:3264-3273, 2018; PubMed: 30156264; DOI: 10.1002/1873-3468.13231

実験手法

X-RAY DIFFRACTION (1.983 Å)