6H1V

The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster

Summary for 6H1V

• Entry DOI: 10.2210/pdb6h1v/pdb
• Related: 6gzg
• Descriptor: DNA polymerase epsilon catalytic subunit A, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), DNA (5'-D(P*AP*AP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3'), ... (7 entities in total)
• Functional Keywords: pol epsilon, m644g, dna, complex, dna binding protein, fe-s
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Total number of polymer chains: 3
• Total formula weight: 145787.77

Authors

Parkash, V.,Johansson, E. (deposition date: 2018-07-12, release date: 2019-04-24, Last modification date: 2024-01-17)

• Primary citation: Ter Beek, J.,Parkash, V.,Bylund, G.O.,Osterman, P.,Sauer-Eriksson, A.E.,Johansson, E.; Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.; Nucleic Acids Res., 47:5712-5722, 2019; PubMed: 30968138; DOI: 10.1093/nar/gkz248

Experimental method

X-RAY DIFFRACTION (2.7 Å)