6H1V
The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase epsilon catalytic subunit A | polymer | 1187 | 136738.3 | 1 | UniProt (P21951) Pfam (PF03104) Pfam (PF22634) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | DNA polymerase II subunit A |
| 2 | B (P) | DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3') | polymer | 11 | 3293.2 | 1 | synthetic construct | ||
| 3 | C (T) | DNA (5'-D(P*AP*AP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3') | polymer | 16 | 4889.2 | 1 | synthetic construct | ||
| 4 | D (A) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 5 | E (A) | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE | non-polymer | 491.2 | 1 | Chemie (DTP) | |||
| 6 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | G, H (A, P) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 1 - 1187 (UniProt: P21951)
| PDB | External Database | Details |
|---|---|---|
| Ala 290 | Asp 290 | engineered mutation |
| Ala 292 | Glu 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 144920.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 867.1 | |
| All* | Total formula weight | 145787.8 |
