Crystal structure of C21orf127-TRMT112 in complex with SAH and H4 peptide

Summary for 6H1E

DescriptorHemK methyltransferase family member 2, Multifunctional methyltransferase subunit TRM112-like protein, Histone H4 peptide, ... (5 entities in total)
Functional Keywordsprotein methyltransferase, histone methylation, complex, sah, gene regulation
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight39114.99
Wang, S.,Hermann, B.,Metzger, E.,Peng, L.,Einsle, O.,Schuele, R. (deposition date: 2018-07-11, release date: 2019-05-22)
Primary citation
Metzger, E.,Wang, S.,Urban, S.,Willmann, D.,Schmidt, A.,Offermann, A.,Allen, A.,Sum, M.,Obier, N.,Cottard, F.,Ulferts, S.,Preca, B.T.,Hermann, B.,Maurer, J.,Greschik, H.,Hornung, V.,Einsle, O.,Perner, S.,Imhof, A.,Jung, M.,Schule, R.
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.
Nat.Struct.Mol.Biol., 26:361-371, 2019
PubMed: 31061526 (PDB entries with the same primary citation)
DOI: 10.1038/s41594-019-0219-9
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24640 0.7% 2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution