6H0G
Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)
Summary for 6H0G
Entry DOI | 10.2210/pdb6h0g/pdb |
Related | 6H0F |
Descriptor | DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, Zinc finger protein 692, ... (5 entities in total) |
Functional Keywords | e3 ubiquitin ligase, drug mediated protein-interaction, targeted protein degradation, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 297347.78 |
Authors | Bunker, R.D.,Petzold, G.,Thoma, N.H. (deposition date: 2018-07-09, release date: 2018-11-07, Last modification date: 2024-01-17) |
Primary citation | Sievers, Q.L.,Petzold, G.,Bunker, R.D.,Renneville, A.,Slabicki, M.,Liddicoat, B.J.,Abdulrahman, W.,Mikkelsen, T.,Ebert, B.L.,Thoma, N.H. Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science, 362:-, 2018 Cited by PubMed: 30385546DOI: 10.1126/science.aat0572 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.25 Å) |
Structure validation
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