6H0G
Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1 | polymer | 856 | 95773.7 | 2 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (Human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe,DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
2 | B, E | Protein cereblon | polymer | 426 | 48976.1 | 2 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB | Homo sapiens (Human) | |
3 | C, F | Zinc finger protein 692 | polymer | 31 | 3520.0 | 2 | UniProt (Q9BU19) Pfam (PF00096) In PDB | Homo sapiens (Human) | |
4 | B, C, E, F | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
5 | B, E | S-Pomalidomide | non-polymer | 273.2 | 2 | Chemie (Y70) |
Sequence modifications
A, D: 1 - 699 (UniProt: Q16531)
A, D: 700 - 705 (PDB: 6H0G)
A, D: 706 - 1140 (UniProt: Q16531)
B, E: 41 - 442 (UniProt: Q96SW2)
C, F: 413 - 442 (UniProt: Q9BU19)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
Val -12 | - | expression tag |
Asp -11 | - | expression tag |
Glu -10 | - | expression tag |
Glu -9 | - | expression tag |
Asn -8 | - | expression tag |
Leu -7 | - | expression tag |
Tyr -6 | - | expression tag |
Phe -5 | - | expression tag |
Gln -4 | - | expression tag |
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
A, D: 706 - 1140 (UniProt: Q16531)
B, E: 41 - 442 (UniProt: Q96SW2)
PDB | External Database | Details |
---|---|---|
Met 17 | - | initiating methionine |
Asp 18 | - | expression tag |
Trp 19 | - | expression tag |
Ser 20 | - | expression tag |
His 21 | - | expression tag |
Pro 22 | - | expression tag |
Gln 23 | - | expression tag |
Phe 24 | - | expression tag |
Glu 25 | - | expression tag |
Lys 26 | - | expression tag |
Ser 27 | - | expression tag |
Ala 28 | - | expression tag |
Val 29 | - | expression tag |
Asp 30 | - | expression tag |
Glu 31 | - | expression tag |
Asn 32 | - | expression tag |
Leu 33 | - | expression tag |
Tyr 34 | - | expression tag |
Phe 35 | - | expression tag |
Gln 36 | - | expression tag |
Gly 37 | - | expression tag |
Gly 38 | - | expression tag |
Gly 39 | - | expression tag |
Arg 40 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 412 | - | expression tag |
Gly 414 | Glu 419 | conflict |
Arg 415 | Lys 420 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 296539.7 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 808.1 | |
All* | Total formula weight | 297347.8 |