6H0G

Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1	polymer	856	95773.7	2	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178)	Homo sapiens (Human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe,DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
2	B, E (B, E)	Protein cereblon	polymer	426	48976.1	2	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (Human)
3	C, F (C, F)	Zinc finger protein 692	polymer	31	3520.0	2	UniProt (Q9BU19) Pfam (PF00096)	Homo sapiens (Human)
4	G, I, J, L (B, C, E, F)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	H, K (B, E)	S-Pomalidomide	non-polymer		273.2	2	Chemie (Y70)

Sequence modifications

A, D: 1 - 699 (UniProt: Q16531)

PDB	External Database	Details
Met -19	-	initiating methionine
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
Val -12	-	expression tag
Asp -11	-	expression tag
Glu -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

A, D: 700 - 705 (PDB: 6H0G)
A, D: 706 - 1140 (UniProt: Q16531)
B, E: 41 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Met 17	-	initiating methionine
Asp 18	-	expression tag
Trp 19	-	expression tag
Ser 20	-	expression tag
His 21	-	expression tag
Pro 22	-	expression tag
Gln 23	-	expression tag
Phe 24	-	expression tag
Glu 25	-	expression tag
Lys 26	-	expression tag
Ser 27	-	expression tag
Ala 28	-	expression tag
Val 29	-	expression tag
Asp 30	-	expression tag
Glu 31	-	expression tag
Asn 32	-	expression tag
Leu 33	-	expression tag
Tyr 34	-	expression tag
Phe 35	-	expression tag
Gln 36	-	expression tag
Gly 37	-	expression tag
Gly 38	-	expression tag
Gly 39	-	expression tag
Arg 40	-	expression tag

C, F: 413 - 442 (UniProt: Q9BU19)

PDB	External Database	Details
Gly 412	-	expression tag
Gly 414	Glu 419	conflict
Arg 415	Lys 420	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	296539.7
Non-Polymers*	Number of molecules	6
	Total formula weight	808.1
All*	Total formula weight	297347.8

*Water molecules are not included.