6H0G

Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005634	cellular_component	nucleus
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0030177	biological_process	positive regulation of Wnt signaling pathway
B	0031333	biological_process	negative regulation of protein-containing complex assembly
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
B	0035641	biological_process	locomotory exploration behavior
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0060173	biological_process	limb development
D	0003676	molecular_function	nucleic acid binding
D	0005634	cellular_component	nucleus
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0016020	cellular_component	membrane
E	0016567	biological_process	protein ubiquitination
E	0030177	biological_process	positive regulation of Wnt signaling pathway
E	0031333	biological_process	negative regulation of protein-containing complex assembly
E	0031334	biological_process	positive regulation of protein-containing complex assembly
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
E	0035641	biological_process	locomotory exploration behavior
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044325	molecular_function	transmembrane transporter binding
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0060173	biological_process	limb development

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 501

Chain	Residue
B	CYS323
B	CYS326
B	CYS391
B	CYS394

---

site_id	AC2
Number of Residues	10
Details	binding site for residue Y70 B 502

Chain	Residue
B	TRP386
B	TRP400
B	PHE402
C	GLN418
C	GLY423
B	ASN351
B	PRO352
B	GLU377
B	HIS378
B	TRP380

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 501

Chain	Residue
C	CYS419
C	CYS422
C	HIS435
C	HIS439

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN E 501

Chain	Residue
E	CYS323
E	CYS326
E	CYS391
E	CYS394

---

site_id	AC5
Number of Residues	15
Details	binding site for residue Y70 E 502

Chain	Residue
E	ASN351
E	PRO352
E	HIS353
E	GLU377
E	HIS378
E	SER379
E	TRP380
E	TRP386
E	TRP400
E	PHE402
F	GLN418
F	CYS419
F	GLU420
F	CYS422
F	GLY423

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN F 501

Chain	Residue
F	CYS419
F	CYS422
F	HIS435
F	HIS439

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cei..CgftCrqkaslnwHqrk..H

Chain	Residue	Details
C	CYS419-HIS439

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	686
Details	Region: {"description":"WD repeat beta-propeller A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	668
Details	Region: {"description":"WD repeat beta-propeller C"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	738
Details	Region: {"description":"Interaction with CDT1 and CUL4A","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	476
Details	Domain: {"description":"Lon N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01123","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	216
Details	Domain: {"description":"CULT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25108355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TZ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	44
Details	Zinc finger: {"description":"C2H2-type 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---