6H0G

Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005634	cellular_component	nucleus
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0030177	biological_process	positive regulation of Wnt signaling pathway
B	0031333	biological_process	negative regulation of protein-containing complex assembly
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
B	0035641	biological_process	locomotory exploration behavior
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
D	0003676	molecular_function	nucleic acid binding
D	0005634	cellular_component	nucleus
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0016020	cellular_component	membrane
E	0016567	biological_process	protein ubiquitination
E	0030177	biological_process	positive regulation of Wnt signaling pathway
E	0031333	biological_process	negative regulation of protein-containing complex assembly
E	0031334	biological_process	positive regulation of protein-containing complex assembly
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
E	0035641	biological_process	locomotory exploration behavior
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044325	molecular_function	transmembrane transporter binding
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 501

Chain	Residue
B	CYS323
B	CYS326
B	CYS391
B	CYS394

---

site_id	AC2
Number of Residues	10
Details	binding site for residue Y70 B 502

Chain	Residue
B	TRP386
B	TRP400
B	PHE402
C	GLN418
C	GLY423
B	ASN351
B	PRO352
B	GLU377
B	HIS378
B	TRP380

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 501

Chain	Residue
C	CYS419
C	CYS422
C	HIS435
C	HIS439

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN E 501

Chain	Residue
E	CYS323
E	CYS326
E	CYS391
E	CYS394

---

site_id	AC5
Number of Residues	15
Details	binding site for residue Y70 E 502

Chain	Residue
E	ASN351
E	PRO352
E	HIS353
E	GLU377
E	HIS378
E	SER379
E	TRP380
E	TRP386
E	TRP400
E	PHE402
F	GLN418
F	CYS419
F	GLU420
F	CYS422
F	GLY423

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN F 501

Chain	Residue
F	CYS419
F	CYS422
F	HIS435
F	HIS439

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cei..CgftCrqkaslnwHqrk..H

Chain	Residue	Details
C	CYS419-HIS439

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269|PubMed:25108355, ECO:0007744|PDB:4TZ4

Chain	Residue	Details
B	CYS323
E	HIS378
E	TRP380
E	TRP386
E	CYS391
E	CYS394
B	CYS326
B	HIS378
B	TRP380
B	TRP386
B	CYS391
B	CYS394
E	CYS323
E	CYS326

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS1067
D	LYS1067

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0

Chain	Residue	Details
A	THR1125
D	THR1125

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS1121
D	LYS1121

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