6H0G

Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)

6H0G の概要

• エントリーDOI: 10.2210/pdb6h0g/pdb
• 関連するPDBエントリー: 6H0F
• 分子名称: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, Zinc finger protein 692, ... (5 entities in total)
• 機能のキーワード: e3 ubiquitin ligase, drug mediated protein-interaction, targeted protein degradation, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 297347.78

構造登録者

Bunker, R.D.,Petzold, G.,Thoma, N.H. (登録日: 2018-07-09, 公開日: 2018-11-07, 最終更新日: 2024-01-17)

• 主引用文献: Sievers, Q.L.,Petzold, G.,Bunker, R.D.,Renneville, A.,Slabicki, M.,Liddicoat, B.J.,Abdulrahman, W.,Mikkelsen, T.,Ebert, B.L.,Thoma, N.H.; Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.; Science, 362:-, 2018; PubMed: 30385546; DOI: 10.1126/science.aat0572

実験手法

X-RAY DIFFRACTION (4.25 Å)