6H0F
Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2)
Summary for 6H0F
Entry DOI | 10.2210/pdb6h0f/pdb |
Descriptor | DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, DNA-binding protein Ikaros, ... (6 entities in total) |
Functional Keywords | e3 ubiquitin ligase, drug mediated protein-interaction, targeted protein degradation, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 597390.68 |
Authors | Petzold, G.,Bunker, R.D.,Thoma, N.H. (deposition date: 2018-07-09, release date: 2018-11-07, Last modification date: 2024-01-17) |
Primary citation | Sievers, Q.L.,Petzold, G.,Bunker, R.D.,Renneville, A.,Slabicki, M.,Liddicoat, B.J.,Abdulrahman, W.,Mikkelsen, T.,Ebert, B.L.,Thoma, N.H. Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science, 362:eaat0572-, 2018 Cited by PubMed: 30385546DOI: 10.1126/science.aat0572 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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