6H0B

Crystal structure of the human GalNAc-T4 in complex with UDP, manganese and the diglycopeptide 6.

6H0B の概要

• エントリーDOI: 10.2210/pdb6h0b/pdb
• 分子名称: Polypeptide N-acetylgalactosaminyltransferase 4, ALA-THR-GLY-ALA-GLY-ALA-GLY-ALA-GLY-THR-THR-PRO-GLY-PRO-GLY, 1,2-ETHANEDIOL, ... (8 entities in total)
• 機能のキーワード: galnac-ts, galnac-t4, short-range glycosylation preference, long-range glycosylation preference, (glyco)peptides, std-nmr, molecular dynamics, enzyme kinetics, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 137938.85

構造登録者

de las Rivas, M.,Daniel, E.J.P.,Coelho, H.,Lira-Navarrete, E.,Raich, L.,Companon, I.,Diniz, A.,Lagartera, L.,Jimenez-Barbero, J.,Clausen, H.,Rovira, C.,Marcelo, F.,Corzana, F.,Gerken, T.A.,Hurtado-Guerrero, R. (登録日: 2018-07-08, 公開日: 2018-10-10, 最終更新日: 2024-01-17)

• 主引用文献: de Las Rivas, M.,Paul Daniel, E.J.,Coelho, H.,Lira-Navarrete, E.,Raich, L.,Companon, I.,Diniz, A.,Lagartera, L.,Jimenez-Barbero, J.,Clausen, H.,Rovira, C.,Marcelo, F.,Corzana, F.,Gerken, T.A.,Hurtado-Guerrero, R.; Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.; ACS Cent Sci, 4:1274-1290, 2018; PubMed: 30276263; DOI: 10.1021/acscentsci.8b00488

実験手法

X-RAY DIFFRACTION (1.8 Å)