6GZD

Crystal structure of Human CSNK1A1 with A86

6GZD の概要

• エントリーDOI: 10.2210/pdb6gzd/pdb
• 分子名称: Casein kinase I isoform alpha, DIMETHYL SULFOXIDE, TRIETHYLENE GLYCOL, ... (8 entities in total)
• 機能のキーワード: ckia, casein kinase, kinase inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45224.63

構造登録者

Ben-Neriah, Y.,Venkatachalam, A.,Minzel, W.,Fink, A.,Snir-Alkalay, I.,Vacca, J. (登録日: 2018-07-03, 公開日: 2018-08-29, 最終更新日: 2024-01-17)

• 主引用文献: Minzel, W.,Venkatachalam, A.,Fink, A.,Hung, E.,Brachya, G.,Burstain, I.,Shaham, M.,Rivlin, A.,Omer, I.,Zinger, A.,Elias, S.,Winter, E.,Erdman, P.E.,Sullivan, R.W.,Fung, L.,Mercurio, F.,Li, D.,Vacca, J.,Kaushansky, N.,Shlush, L.,Oren, M.,Levine, R.,Pikarsky, E.,Snir-Alkalay, I.,Ben-Neriah, Y.; Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.; Cell, 175:171-185.e25, 2018; PubMed: 30146162; DOI: 10.1016/j.cell.2018.07.045

実験手法

X-RAY DIFFRACTION (2.28 Å)