6GYR
Transcription factor dimerization activates the p300 acetyltransferase
Summary for 6GYR
Entry DOI | 10.2210/pdb6gyr/pdb |
Related | 6GYT |
Descriptor | Histone acetyltransferase p300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate (3 entities in total) |
Functional Keywords | p300, cbp, acetyltransferase, chromatin, transcriptional regulation, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 279503.87 |
Authors | Panne, D.,Ortega, E. (deposition date: 2018-07-01, release date: 2018-10-17, Last modification date: 2024-01-17) |
Primary citation | Ortega, E.,Rengachari, S.,Ibrahim, Z.,Hoghoughi, N.,Gaucher, J.,Holehouse, A.S.,Khochbin, S.,Panne, D. Transcription factor dimerization activates the p300 acetyltransferase. Nature, 562:538-544, 2018 Cited by PubMed: 30323286DOI: 10.1038/s41586-018-0621-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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