6GX8

Alpha-galactosidase from Thermotoga maritima in complex with hydrolysed cyclohexene-based carbasugar mimic of galactose

6GX8 の概要

• エントリーDOI: 10.2210/pdb6gx8/pdb
• 関連するPDBエントリー: 6GTA 6GVD 6GWF 6GWG
• 分子名称: Alpha-galactosidase, SULFATE ION, (1~{S},2~{S},3~{S},4~{S})-3-fluoranyl-6-(hydroxymethyl)cyclohex-5-ene-1,2,4-triol, ... (6 entities in total)
• 機能のキーワード: glycoside hydrolase, galactosidase, carbohydrate processing enzyme, inhibitor, hydrolase
• 由来する生物種: Thermotoga maritima MSB8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66780.84

構造登録者

Gloster, T.M.,Oehler, V. (登録日: 2018-06-26, 公開日: 2018-08-22, 最終更新日: 2024-01-17)

• 主引用文献: Ren, W.,Pengelly, R.,Farren-Dai, M.,Shamsi Kazem Abadi, S.,Oehler, V.,Akintola, O.,Draper, J.,Meanwell, M.,Chakladar, S.,Swiderek, K.,Moliner, V.,Britton, R.,Gloster, T.M.,Bennet, A.J.; Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.; Nat Commun, 9:3243-3243, 2018; PubMed: 30104598; DOI: 10.1038/s41467-018-05702-7

実験手法

X-RAY DIFFRACTION (1.42 Å)