6GTA

Alpha-galactosidase mutant D378A from Thermotoga maritima in complex with intact cyclohexene-based carbasugar mimic of galactose with 3,5 difluorophenyl leaving group

Summary for 6GTA

• Entry DOI: 10.2210/pdb6gta/pdb
• Descriptor: Alpha-galactosidase, SULFATE ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: glycoside hydrolase, galactosidase, carbohydrate processing enzyme, inhibitor, hydrolase
• Biological source: Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
• Total number of polymer chains: 1
• Total formula weight: 66779.13

Authors

Gloster, T.M.,Pengelly, R.J. (deposition date: 2018-06-17, release date: 2018-08-22, Last modification date: 2024-01-17)

• Primary citation: Ren, W.,Pengelly, R.,Farren-Dai, M.,Shamsi Kazem Abadi, S.,Oehler, V.,Akintola, O.,Draper, J.,Meanwell, M.,Chakladar, S.,Swiderek, K.,Moliner, V.,Britton, R.,Gloster, T.M.,Bennet, A.J.; Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.; Nat Commun, 9:3243-3243, 2018; PubMed: 30104598; DOI: 10.1038/s41467-018-05702-7

Experimental method

X-RAY DIFFRACTION (2.2 Å)