6GX8
Alpha-galactosidase from Thermotoga maritima in complex with hydrolysed cyclohexene-based carbasugar mimic of galactose
Summary for 6GX8
Entry DOI | 10.2210/pdb6gx8/pdb |
Related | 6GTA 6GVD 6GWF 6GWG |
Descriptor | Alpha-galactosidase, SULFATE ION, (1~{S},2~{S},3~{S},4~{S})-3-fluoranyl-6-(hydroxymethyl)cyclohex-5-ene-1,2,4-triol, ... (6 entities in total) |
Functional Keywords | glycoside hydrolase, galactosidase, carbohydrate processing enzyme, inhibitor, hydrolase |
Biological source | Thermotoga maritima MSB8 |
Total number of polymer chains | 1 |
Total formula weight | 66780.84 |
Authors | Gloster, T.M.,Oehler, V. (deposition date: 2018-06-26, release date: 2018-08-22, Last modification date: 2024-01-17) |
Primary citation | Ren, W.,Pengelly, R.,Farren-Dai, M.,Shamsi Kazem Abadi, S.,Oehler, V.,Akintola, O.,Draper, J.,Meanwell, M.,Chakladar, S.,Swiderek, K.,Moliner, V.,Britton, R.,Gloster, T.M.,Bennet, A.J. Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level. Nat Commun, 9:3243-3243, 2018 Cited by PubMed: 30104598DOI: 10.1038/s41467-018-05702-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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