6GS4

Crystal structure of peptide transporter DtpA-nanobody in complex with valganciclovir

Summary for 6GS4

Entry DOI	10.2210/pdb6gs4/pdb
Descriptor	Dipeptide and tripeptide permease A, nanobody, [(2~{S})-2-[(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)methoxy]-3-oxidanyl-propyl] (2~{S})-2-azanyl-3-methyl-butanoate, ... (5 entities in total)
Functional Keywords	peptide transporter, membrane protein, complex with nanobody, slc15 family member
Biological source	Escherichia coli K-12 More
Total number of polymer chains	2
Total formula weight	70235.34
Authors	Ural-Blimke, Y.,Flayhan, A.,Quistgaard, E.M.,Loew, C. (deposition date: 2018-06-13, release date: 2019-01-30, Last modification date: 2024-01-17)
Primary citation	Ural-Blimke, Y.,Flayhan, A.,Strauss, J.,Rantos, V.,Bartels, K.,Nielsen, R.,Pardon, E.,Steyaert, J.,Kosinski, J.,Quistgaard, E.M.,Low, C. Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1. J. Am. Chem. Soc., 141:2404-2412, 2019 Cited by PubMed: 30644743 DOI: 10.1021/jacs.8b11343 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.645 Å)

Structure validation