6GPS
CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812
Summary for 6GPS
Entry DOI | 10.2210/pdb6gps/pdb |
Related | 5t1a |
Descriptor | C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2, ZINC ION, [(3~{S},4~{S})-3-methoxyoxan-4-yl]-[(1~{R},3~{S})-3-propan-2-yl-3-[[3-(trifluoromethyl)-7,8-dihydro-5~{H}-1,6-naphthyridin-6-yl]carbonyl]cyclopentyl]azanium (3 entities in total) |
Functional Keywords | gpcr, signalling, drug-design, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 48814.14 |
Authors | Pautsch, A.,Schnapp, G. (deposition date: 2018-06-07, release date: 2019-01-02, Last modification date: 2019-03-13) |
Primary citation | Apel, A.K.,Cheng, R.K.Y.,Tautermann, C.S.,Brauchle, M.,Huang, C.Y.,Pautsch, A.,Hennig, M.,Nar, H.,Schnapp, G. Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists. Structure, 27:427-438.e5, 2019 Cited by PubMed: 30581043DOI: 10.1016/j.str.2018.10.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
Download full validation report